Title

Comparative Genomics: The Next Generation

Authors

Leslie A. Lyons, National Cancer Institute at Frederick
M. M. Raymond, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

1994

Publication Title

Animal Biotechnology

ISSN

1049-5398

Volume

5

Issue/No.

2

First Page

103

Last Page

111

Abstract

Recent advances in human gene mapping technologies have led to increased emphasis in developing representative genetic maps for several species, particularly domestic plants and animals. These maps are being compiled with two distinct goals: to provide a resource for genetic analysis, and to help dissect the evolution of genome organization by comparing linkage relationships of homologous genes. We recently proposed a list of reference anchor loci suitable for comparative gene mapping in mammals and other vertebrate classes. The comparative anchors, which are Type I (coding gene) loci, provide a comparative framework, but the addition of Type II (microsatellite) loci is also necessary for mapping phenotypes in animal gene maps. Strategies for combining the advantages of Type I and Type II locus markers are presented with emphasis on application of these concepts to the construction of a gene map of the domestic cat.

NSUWorks Citation

Lyons, Leslie A.; M. M. Raymond; and Stephen J. O'Brien. 1994. "Comparative Genomics: The Next Generation." Animal Biotechnology 5, (2): 103-111. https://nsuworks.nova.edu/cnso_bio_facarticles/256

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015