Biology Faculty Articles

Title

Akvr-1, a Dominant Murine Leukemia Virus Restriction Gene, is Polymorphic in Leukemia-Prone Wild Mice

Document Type

Article

Publication Date

1-15-1980

Publication Title

Proceedings of the National Academy of Sciences of the United States of America

Keywords

Murine leukemia virus regulation, Retrovirus control gene

ISSN

1091-6490

Volume

77

Issue/No.

1

First Page

531

Last Page

535

Abstract

We describe a restriction gene (Akvr-1, for AKR virus restriction) that is polymorphic for two alleles, Akvr-1R (restrictive) and Akvr-1r (susceptible), in a feral population of mice (Mus musculus domesticus) at a squab farm near Lake Casitas (LC) in southern California. Akvr-1R is a dominant allele that exhibits 100% penetrance in prevention of viremia of AKR endogenous retrovirus and of virus-mediated lymphoma in LC (Akvr-1RR) X AKR F1 hybrids. The restriction phenotype segregates as a single Mendelian locus in backcrosses to AKR mice. Akvr-1R likewise is effective in restriction of NB-tropic Moloney murine leukemia virus-induced viremia and NB-tropic Friend virus-induced splenomegaly but fails to restrict expression or pathogenesis of LC-derived amphotropic retrovirus. Pleiotropic restriction of AKR, Friend, and Moloney ecotropic viruses, but not of amphotropic virus, suggests that the viral targets of Akvr-1 in the three ecotropic viruses are similar to each other and distinct from the target in the LC-amphotropic virus. The relationship of Akvr-1 to previously reported murine restriction loci Fv-1, Fv-2, and Fv-4 is discussed.

Additional Comments

Contract #N01-CP8-1032

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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