Title

A Molecular Phylogeny of the Hominoid Primates as Indicated by Two-Dimensional Protein Electrophoresis

Authors

David Goldman, National Institute on Alcohol Abuse and Alcoholism
P. Rathna Giri, National Institute on Alcohol Abuse and Alcoholism
Stephen J. O'Brien, National Cancer Institute at FrederickFollow

Document Type

Article

Publication Date

5-15-1987

Publication Title

Proceedings of the National Academy of Sciences of the United States of America

Keywords

Genetic distance

ISSN

1091-6490

Volume

84

Issue/No.

10

First Page

3307

Last Page

3311

Abstract

A molecular phylogeny for the hominoid primates was constructed by using genetic distances from a survey of 383 radiolabeled fibroblast polypeptides resolved by two-dimensional electrophoresis (2DE). An internally consistent matrix of Nei genetic distances was generated on the basis of variants in electrophoretic position. The derived phylogenetic tree indicated a branching sequence, from oldest to most recent, of cercopithecoids (Macaca fascicularis), gibbon-siamang, orangutan, gorilla, and human-chimpanzee. A cladistic analysis of 240 electrophoretic characters that varied between ape species produced an identical tree. Genetic distance measures obtained by 2DE are largely consistent with those generated by other molecular procedures. In addition, the 2DE data set appears to resolve the human-chimpanzee-gorilla trichotomy in favor of a more recent association of chimpanzees and humans.

NSUWorks Citation

Goldman, David; P. Rathna Giri; and Stephen J. O'Brien. 1987. "A Molecular Phylogeny of the Hominoid Primates as Indicated by Two-Dimensional Protein Electrophoresis." Proceedings of the National Academy of Sciences of the United States of America 84, (10): 3307-3311. https://nsuworks.nova.edu/cnso_bio_facarticles/245

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015