Biology Faculty Articles

Title

Conserved Chromosomal Positions of Dual Domains of the ets Protooncogene in Cats, Mice, and Humans

Document Type

Article

Publication Date

3-15-1986

Publication Title

Proceedings of the National Academy of Sciences of the United States of America

Keywords

Comparative gene mapping, Leukemia

ISSN

1091-6490

Volume

83

Issue/No.

6

First Page

1792

Last Page

1796

Abstract

The mammalian protooncogene homologue of the avian v-ets sequence from the E26 retrovirus consists of two sequentially distinct domains located on different chromosomes. Using somatic cell hybrid panels, we have mapped the mammalian homologue of the 5' v-ets-domain to chromosome 11 (ETS1) in man, to chromosome 9 (Ets-1) in mouse, and to chromosome D1 (ETS1) in the domestic cat. The mammalian homologue of the 3' v-ets domain was similarly mapped to human chromosome 21 (ETS2), to mouse chromosome 16 (Ets-2), and to feline chromosome C2 (ETS2). Both protooncogenes fell in syntenic groups of homologous linked loci that were conserved among the three species. The occurrence of two distinct functional protooncogenes and their conservation of linkage positions in the three mammalian orders indicate that these two genes have been separate since before the evolutionary divergence of mammals.

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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