Title

Establishment and Characterization of Three New Continuous Cell Lines Derived from Human Breast Carcinomas

Authors

Linda W. Engel, National Cancer Institute at Bethesda
Nathaniel A. Young, National Cancer Institute at Bethesda
Tommie Sue Tralka, National Cancer Institute at Bethesda
Marc E. Lippman, National Cancer Institute at Bethesda
Stephen J. O'Brien, National Cancer Institute at BethesdaFollow
Mary Jo Joyce, National Cancer Institute at Bethesda

Document Type

Article

Publication Date

10-1978

Publication Title

Cancer Research

ISSN

0008-5472

Volume

38

Issue/No.

10

First Page

3352

Last Page

3364

Abstract

Three continuous lines of mammary tumor cells (ZR-75-1, ZR-75-27, and ZR-75-30) have been established from malignant effusions of two women with breast cancer. Differentiated properties expressed by each cell line include: (a) epithelial morphology (by light and electron microscopy) resembling that of the parental tumors; (b) presence of receptors for estrogen and other steroid hormones; and (c) growth responsiveness to estrogen and/or progesterone. All three cell lines possess human karyotypes that differ from one another in modal chromosome number as well as in characteristic marker chromosomes. Two of the cultures (ZR-75-27 and ZR-75-30), although derived from the same patient, have stable differences in their karyotypes.

Comments

©1978 American Association for Cancer Research

NSUWorks Citation

Engel, Linda W.; Nathaniel A. Young; Tommie Sue Tralka; Marc E. Lippman; Stephen J. O'Brien; and Mary Jo Joyce. 1978. "Establishment and Characterization of Three New Continuous Cell Lines Derived from Human Breast Carcinomas." Cancer Research 38, (10): 3352-3364. https://nsuworks.nova.edu/cnso_bio_facarticles/186

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015