Biology Faculty Articles

Title

Establishment and Characterization of Three New Continuous Cell Lines Derived from Human Breast Carcinomas

Document Type

Article

Publication Date

10-1978

Publication Title

Cancer Research

ISSN

0008-5472

Volume

38

Issue/No.

10

First Page

3352

Last Page

3364

Abstract

Three continuous lines of mammary tumor cells (ZR-75-1, ZR-75-27, and ZR-75-30) have been established from malignant effusions of two women with breast cancer. Differentiated properties expressed by each cell line include: (a) epithelial morphology (by light and electron microscopy) resembling that of the parental tumors; (b) presence of receptors for estrogen and other steroid hormones; and (c) growth responsiveness to estrogen and/or progesterone. All three cell lines possess human karyotypes that differ from one another in modal chromosome number as well as in characteristic marker chromosomes. Two of the cultures (ZR-75-27 and ZR-75-30), although derived from the same patient, have stable differences in their karyotypes.

Comments

©1978 American Association for Cancer Research

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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