Title

Genetic Variance of Laboratory Outbred Swiss Mice

Authors

M. Catherine Rice, National Cancer Institute at Bethesda
Stephen J. O'Brien, National Cancer Institute at BethesdaFollow

Document Type

Article

Publication Date

1-10-1980

Publication Title

Nature

ISSN

0028-0836

Volume

283

Issue/No.

5743

First Page

157

Last Page

161

Abstract

The extent of allelic variation has been estimated at 46 structural gene loci within three major colonies of Swiss mice and between inbred derivative strains. The colonies have retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for more than 50 years (175 generations). The population genetic structures of the Swiss mouse colonies were comparable to an island population in which random fixation, and not inbreeding or population bottlenecks, is apparently responsible for slight losses in genetic variance.

Comments

©1980 Macmillan Journals Ltd

NSUWorks Citation

Rice, M. Catherine and Stephen J. O'Brien. 1980. "Genetic Variance of Laboratory Outbred Swiss Mice." Nature 283, (5743): 157-161. doi:10.1038/283157a0.

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

DOI

10.1038/283157a0