Title

Mapping of an Endogenous Retroviral Sequence to Human Chromosome 18

Authors

Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Tom I. Bonner, National Cancer Institute at Frederick
Maurice Cohen, National Cancer Institute at Frederick
Cathy O'Connell, National Cancer Institute at Frederick
William Nash, National Cancer Institute at Frederick

Document Type

Article

Publication Date

5-5-1983

Publication Title

Nature

ISSN

0028-0836

Volume

303

Issue/No.

5912

First Page

74

Last Page

77

Abstract

The application of recombinant DNA technologies has allowed the detection of at least three families of moderately repetitive DNA segments in the human genome that are homologous to retroviruses previously isolated from mice and primates. One of these DNA segments has been shown by nucleotide sequence comparisons to be distantly related to both Moloney murine leukaemia virus (MoMuLV) and the endogenous baboon retrovirus and to have the sequence organization characteristic of an integrated retrovirus. Isolation of the homologous locus from chimpanzee DNA indicated that the integration event preceded the evolutionary divergence of chimpanzees and man. Here we have used a panel of rodent × human somatic cell hybrids to assign the chromosomal localization of this segment, called ERV1 (endogenous retrovirus-1), to human chromosome 18 (HSA 18).

Comments

©1983 Nature Publishing Group

NSUWorks Citation

O'Brien, Stephen J.; Tom I. Bonner; Maurice Cohen; Cathy O'Connell; and William Nash. 1983. "Mapping of an Endogenous Retroviral Sequence to Human Chromosome 18." Nature 303, (5912): 74-77. doi:10.1038/303074a0.

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

DOI

10.1038/303074a0