Biology Faculty Articles

Title

The Human Homologs of the raf (mil) Oncogene are Located on Human Chromosomes 3 and 4

Document Type

Article

Publication Date

1-6-1984

Publication Title

Science

ISSN

0036-8075

Volume

223

Issue/No.

4631

First Page

71

Last Page

74

Abstract

Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.

Comments

©1984 American Association for the Advancement of Science

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

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