Title

The Human Homologs of the raf (mil) Oncogene are Located on Human Chromosomes 3 and 4

Authors

Tom I. Bonner, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
William Nash, National Cancer Institute at Frederick
Ulf R. Rapp, National Cancer Institute at Frederick
Cynthia C. Morton, Harvard Medical School
Philip Leder, Harvard Medical School

Document Type

Article

Publication Date

1-6-1984

Publication Title

Science

ISSN

0036-8075

Volume

223

Issue/No.

4631

First Page

71

Last Page

74

Abstract

Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.

Comments

©1984 American Association for the Advancement of Science

NSUWorks Citation

Bonner, Tom I.; Stephen J. O'Brien; William Nash; Ulf R. Rapp; Cynthia C. Morton; and Philip Leder. 1984. "The Human Homologs of the raf (mil) Oncogene are Located on Human Chromosomes 3 and 4." Science 223, (4631): 71-74. doi:10.1126/science.6691137.

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015

DOI

10.1126/science.6691137