Title

Identification of an Amplified, Highly Expressed Gene in a Human Glioma

Authors

Kenneth W. Kinzler, Johns Hopkins University School of Medicine
Sandra H. Bigner, Duke University Medical Center
Darrell D. Bigner, Duke University Medical Center
Jeffrey M. Trent, University of Arizona - Tucson
Martha L. Law, University of Colorado - Denver
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Albert J. Wong, Johns Hopkins University School of Medicine
Bert Vogelstein, Johns Hopkins University School of Medicine

Document Type

Article

Publication Date

4-3-1987

Publication Title

Science

ISSN

0036-8075

Volume

236

Issue/No.

4797

First Page

70

Last Page

73

Abstract

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

Comments

©1987 American Association for the Advancement of Science

NSUWorks Citation

Kinzler, Kenneth W.; Sandra H. Bigner; Darrell D. Bigner; Jeffrey M. Trent; Martha L. Law; Stephen J. O'Brien; Albert J. Wong; and Bert Vogelstein. 1987. "Identification of an Amplified, Highly Expressed Gene in a Human Glioma." Science 236, (4797): 70-73. https://nsuworks.nova.edu/cnso_bio_facarticles/155

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015