Title

The Human Myelin-Basic-Protein Gene: Chromosomal Localization and RFLP Analysis

Authors

John Kamholz, National Institutes of Health at Bethesda
Richard Spielman, University of Pennsylvania
William Modi, National Cancer Institute at Frederick
Stephen J. O'Brien, National Cancer Institute at FrederickFollow
Robert Lazzarini, National Cancer Institute at Frederick

Document Type

Article

Publication Date

4-1987

Publication Title

American Journal of Human Genetics

ISSN

0002-9297

Volume

40

Issue/No.

4

First Page

365

Last Page

373

Abstract

With a human myelin-basic-protein (MBP) cDNA used as a probe, the human MBP gene has been mapped to chromosome region 18q22-q23 by a combination of Southern hybridization to a panel of somatic-cell hybrid DNAs and in situ hybridization to metaphase chromosomes. Restriction-fragment-length polymorphisms (RFLPs) have also been identified with this probe in human DNA, by means of the restriction enzymes BamHI, PvuII, and PstI. In studies of informative families, the alleles of the BamHI and PvuII polymorphisms have been shown to segregate as Mendelian traits.

Comments

©1987 by the American Society of Human Genetics

Additional Comments

National Multiple Sclerosis Society grant: RG1441; National Institutes of Health grant: GM32592

NSUWorks Citation

Kamholz, John; Richard Spielman; William Modi; Stephen J. O'Brien; and Robert Lazzarini. 1987. "The Human Myelin-Basic-Protein Gene: Chromosomal Localization and RFLP Analysis." American Journal of Human Genetics 40, (4): 365-373. https://nsuworks.nova.edu/cnso_bio_facarticles/150

ORCID ID

0000-0001-7353-8301

ResearcherID

N-1726-2015