Biology Faculty Articles

Document Type

Article

Publication Date

3-27-2021

Publication Title

Advanced Journal of Graduate Research

Keywords

14-3-3 protein, YWHA, 14-3-3 isoforms, binding partners, mammals

ISSN

2456-7108

Volume

10

Issue/No.

1

First Page

16

Last Page

22

Abstract

The 14-3-3 (YWHA or Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation proteins) are a family of abundant, highly conserved, ubiquitous, acidic, and homologous proteins expressed in most eukaryotes ranging from plants to animals, including humans, important in regulating a multitude of cellular processes such as signal transduction, cell cycle, protein trafficking, metabolism, apoptosis, and development. Mammals have been noted contain seven isoforms of these proteins (beta, epsilon, eta, gamma, sigma, tau/theta, and zeta), encoded by separate genes. The 14-3-3 proteins are known to interact with over 200 binding partners in isoform-specific, tissue-specific, and developmental stage-specific ways. The present review article encapsulates previously published research articles that report 14-3-3-interactors, and investigates isoform-specific interactions within a wide array of mammalian species, cells, tissues, organs, and developmental stages. Of the hundreds of binding partners of 14-3-3 discovered till date, this paper focuses on analyzing selected, representative interactors with key functional roles. The study would help a better understanding of isoform-specific interactions of this critical protein family in mammals

Comments

Author(s) retains full copyright of their article and grants non-exclusive publishing right to this journal and its publisher “AIJR (India)”. Author(s) can archive pre-print, post-print and published version/PDF to any open access, institutional repository, social media or personal website provided that Published source must be acknowledged with citation and link to publisher version.

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

ORCID ID

0000-0002-0983-7996 , 0000-0002-9739-4039

DOI

10.21467/ajgr.10.1.16-22

Peer Reviewed

Included in

Biology Commons

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